It led to her first starring role in Jonathan Demme's Something Wild (1986), which became a cult favorite.Griffith also starred in the science fiction film Cherry 2000, which went straight to video in 1988 but has also become a cult favorite.
Griffith is a sensational Roxie, possibly the most convincing I have seen" and "[the] vultures who were expecting to see Ms. She played Caan's mother again during 2014–16 in a recurring role on his television show Hawaii Five-0. In the interim, Griffith guest-starred on Nip/Tuck and Hot in Cleveland.Griffith's subsequent performance in Something Wild (1986) garnered critical acclaim before she was cast in 1988's Working Girl, which earned her a nomination for the Academy Award for Best Actress and won her a Golden Globe.The 1990s saw Griffith in a series of roles which received varying critical reception: she received Golden Globe nominations for her performances in Buffalo Girls (1995), and as Marion Davies in RKO 281 (1999), while also earning a Golden Raspberry Award for Worst Actress for her performances in Shining Through (1992), as well as receiving nominations for Crazy in Alabama (1999) and John Waters' cult film Cecil B. Other credits include John Schlesinger's Pacific Heights (1990), Milk Money (1994), the neo-noir film Mulholland Falls (1996), as Charlotte Haze in Adrian Lyne's Lolita (1997), and Another Day in Paradise (1998).Griffith supports the efforts of Children's Hospital Los Angeles helping to lead Walk for Kids, a community 5k, to raise funds as part of the hospital's community awareness efforts in support of the opening of a new state-of-the-art pediatric inpatient facility.She also participated in the hospital's 2012 Noche de Niños gala as a presenter of a Courage to Care Award.In 2000, she co-starred with Stephen Dorff in Cecil B. In 2002, she voiced the character of Margalo the bird in 102 Dalmatians.