The method of claim 62, wherein the subject is suspected of having Reiter's syndrome. A subset of specialized cells express class II MHC.
All nucleated cells express cell surface MHC class I.
The administration may also be at least one of oral, parenteral, subcutaneous, intravenous, intranasal, pulmonary, intramuscular and mucosal administration.
In some embodiments the methods involve administering another medicament to the subject, such as an anti-HIV agent, an anti-viral agent, an anti-parasitic agent, an anti-bacterial agent, an anti-cancer agent, an anti allergic medicament, or an autoimmune medicament.
Peter Gorer and George Snell observed that when tumors were transplanted from a genetically non-identical member of the same species, the tumors were always rejected, but when tumors were transplanted between genetically identical members of the same species, the tumor would “take” and would grow in the syngeneic animal.
The method of claim 62, wherein the subject is suspected of having Acquired immunodeficiency syndrome (AIDS). The MHC molecules are tightly protected in the endosomal/lysosomal compartments to insure that only antigens for which we need a response get presented to T cells.
The activated CD4 cell is also called a helper cell and there are two major categories, Th1 and Th2.
The method of claim 62, wherein the subject is suspected of having Malaria. The invariant chain is associated with MHC class II (and recently shown to be associated with certain MHC class I molecules) prior to antigen loading into the antigen binding grooves of the MHC molecules.
The method of claim 62, wherein the subject is suspected of having African trypanosomiasis. MHC class II molecules, prior to antigen loading, are associated with a molecule called invariant chain, also known as CD74.
The method of claim 62, wherein the subject is suspected of having Hepatitis B. There are two types of MHC molecules: MHC class I and MHC class II.