He did his schooling at Bishop Cotton Boys' School in Bangalore. In 2011 Prabhu was conferred with an honorary doctorate by the Sathyabama University.
He later pursued a BA in History at Loyola College, Chennai.
His family angrily confronts him, when it is revealed that there are actually three ghosts who have possessed him: a violent woman, a Hindi-speaking Muslim, and a mentally retarded boy.
Raghava's family hires an exorcist, who successfully drives the spirit away from Raghava's body.
In the beginning, Ganesan frequently appeared alongside other actors like Rajinikanth, Kamal Hassan, and his father Sivaji Ganesan.
After making his debut in the film Sangili in 1982, he has acted in over 150 films.
He suffers from an irrational fear of ghosts, and retreats to the safety of his home after sunset.
That night, the ghost possesses Raghava, who begins acting increasingly effeminate, alienating himself from Priya and wearing women's clothes and jewellery.On consulting a priest, they perform 3 rituals to ascertain if the house is haunted: 1. A ghost of a woman appears before them and licks the blood.They keep a coconut on a rangoli and pray to Lord Shiva. Scared senseless, Raghava's mother and sister-in-law hire two priests (Om Prakash Rao and Bullet Prakash) to rid their home of the ghost.In 2000 Prabhu appeared in Suyamvaram, which was shot within 24 hours with an extensive cast.He appeared alongside Rajinikanth in Guru Sishyan and Dharmathin Thalaivan (both 1988) and Chandramukhi in 2005, and in Vetri Vizha (1989) and Vasool Raja MBBS (2004) with Kamal Haasan.When his fellow colleagues refused to take up the role of Trisha's brother in Unakkum Enakkum, Prabhu took up the role.