While her emotional pragmatism, competitive perfectionism, and logical nature lead many to view her as a cutthroat "robot", Cristina hits it off with Meredith on their first day and the pair soon become best friends and each other's "person", sharing the same "dark and twisty" sense of humor.
Meredith and Cristina have a fight during the intern scandal, and Cristina chooses Alex to be her replacement. When Izzie Stevens discovers her life-threatening cancer, Yang is the one she confides in over her other friends due to Yang's ability to remain emotionally distant.
Oh originally auditioned for the role of Miranda Bailey, although Chandra Wilson was ultimately cast in the part.
Oh has received generally positive reviews for her portrayal, with Mark Perigard of the Boston Herald considering her friendship with Meredith to be "the secret core of Grey's".
Without a teacher, Yang begins to seriously doubt the purpose of remaining in her place at Seattle Grace when the program falls to twelfth on a list of the best teaching hospitals, and Burke wins the Harper-Avery award without mentioning her at all, despite her saving his career.
Yang tells the Chief that her current existence in the hospital is "unbearable" and that she has turned into a ghost.
She goes on her honeymoon to Hawaii with Meredith to recover, returning to discover that Burke has disappeared from her life and transferred to a different hospital.